Change your Mind with Ayahuasca: Neuroscience of Aya
- Josh Whitaker
- Oct 8, 2024
- 2 min read
Imagine having the power to reshape your own brain, making it more resilient to depression and anxiety while boosting your creativity and happiness.
Surprisingly, recent research suggests that this might be achievable through a fascinating phenomenon called neuroplasticity.

Neuroplasticity, the brain's remarkable ability to rewire and adapt throughout your life, it plays a vital role in your cognitive development, learning, and overall mental well-being.
Recently, microdosing Ayahuasca has gained attention of scientists as a potential tool to enhance neuroplasticity and reengineer the mind.
What is Ayahuasca?
Ayahuasca is a traditional Amazonian brew made from two main plants: Banisteriopsis caapi, which contains monoamine oxidase inhibitors (MAOIs), and Psychotria viridis, which contains the psychedelic compound dimethyltryptamine (DMT).
Ayahuasca ceremonies have been used for centuries in indigenous South American cultures for spiritual and healing purposes.

How Ayahuasca can Rebuild your Brain
1. Neuroplasticity The lasting positive effects of psychedelics has been linked to their ability to rapidly stimulate a period of enhanced neuroplasticity, as well as enduring brain changes [14, 15].This would explain how long-term effects (such as decreased depression and anxiety) outlast the drug’s presence in the body.This theory makes sense as neuroplasticity is often disrupted in the presence of mood disorders and addiction [18].

2. NeurogenesisThe active compounds of Ayahuasca have proven to increase neurogenesis (the creation of new brain cells) [44].Neurogenesis is the process of generating new neurons in the adult brain and is linked to cognitive functions and emotional well-being.Ayahuasca's neurogenic effects may contribute to it's antidepressant activity reported in clinical studies.By stimulating various processes in adult neurogenesis, ayahuasca may be a potential candidate for the development of treatments against neurodegenerative diseases and psychiatric disorders.[44]
3. BNDF (miracle grow for the brain)BDNF, or Brain-Derived Neurotrophic Factor, is like "brain fertilizer." It's a protein in your brain that helps your brain cells grow, communicate, and stay healthy.Individuals treated with ayahuasca showed higher BDNF levels 48 hours after the dosing session compared to those treated with a placebo, regardless of whether they had major depression or were healthy controls. [20]Studies demonstrate that ayahuasca increases BDNF levels, and this increase could be linked to its powerful antidepressant effects.

In conclusion, Ayahuasca, when used responsibly and with proper guidance, holds the potential to enhance brain development through neuroplasticity, neurogenesis, and the promotion of BDNF.Embark on a path to improved mental health and cognitive enhancement while exploring the fascinating landscape of your own mind.Always remember that safety and responsible use are paramount when considering any form of psychedelic experimentation.
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